Prof. Dr. med. Simone Spuler

s-spuler-portrait-neu Wissenschaftliche Leitung der Klinischen Forschergruppe (KFO192),
Arbeitsgruppenleiterin und Leiterin der Spezialambulanz für Muskelkrankheiten

Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!
Telefon: +49 30 450 540501
Fax:      +49 30 450 540907


Experimental and Clinical Research Center (ECRC)
Charité Universitätsmedizin Berlin, Campus Buch
Lindenberger Weg 80, 13125 Berlin, Germany



Verantwortungsbereiche und Projekte

Leitung Institut für Muskelforschung mit Hochschulambulanz für Muskelkrankheiten
Wissenschaftliche Leitung KFO192 – Regulation und Dysregulation von Muskelwachstum
Berlin Sprecherin MyoGrad – Internationales Graduiertenkolleg für Myologie Berlin-Paris
Mitglied der Auswahlkommission des "International Graduate Program Medical Neurosciences" der Charité
Mitglied der Forschungskommission Charité
Vorsitzende des Klinischen Ausbildungsprogramms KAP der Charité



Education

1980-1986
Medical School, University of Würzburg, Germany, Rotations at Harvard
Medical School and Johns Hopkins Medical School, U.S.A.

1986-1987
Internship, Internal Medicine, Universitätskrankenhaus Eppendorf, Hamburg, Director: Prof. Dr. H. Greten

1989-1994
Residency, Dept. of Neurology, Klinikum Großhadern München, Director: Prof. Dr. Th. Brandt in cooperation with Max-Planck-Institut of Psychiatry, Div. Neuroimmunology, Martinsried, Director: Prof. Dr. H. Wekerle


Career/Employment

1995
Faculty rank (Habilitation) in Neurology

2002-2007
Docent (C2): Dept. of Neurology, Charité, Universitätsmedizin Berlin, Director: Prof. Dr. K.M. Einhäupl

08/2007-
Head, Muscle Research Unit, Experimental and Clinical Research Center, Charité and Max-Delbrück Center Berlin


Honors, Awards, Fellowships

2002 and 2005
Teaching Award Medical Neurosciences Charité Medical Faculty, Berlin

2006
Mayo Alumni Research Award

1987-1989
DFG Research Stipend, Laboratory of Mucosal Immunology, University of California, San Diego, La Jolla, U.S.A.

1995-1997
Clinical Fellowship Neuromuscular Diseases, Mayo Clinic, Rochester, MN, U.S.A., Director: Dr. Andrew G. Engel

2007-
Scientific leader of Clinical Research Group (KFO 192) "Regulation and dysregulation of skeletal muscle growth

2010-
Speaker, MyoGrad – Internat. Research Training Group GK1631

2010
Professorship in Faculty for Biology, Chemistry and Pharmacy of the Free University, Berlin


Collaborative Research Projects (selection)

Funding organisation German Research Foundation (DFG)
Project title Regulation and dysregulation of skeletal muscle growth (KFO192), P6: Role of myostatin on dysferlinopathy
Function Scientific leader and principle investigator of P6
Speaker University Charité, Universitätsmedizin Berlin
Project Period 2007-2014

Funding organisation Federal Ministry for Research and Education (BMBF)
Project title SatNet, Fate determination and maintenance of muscle stem cells, P 4 (with Prof. Markus Schülke-Gerstenfeld)
Speaker University FU Berlin
Function Project leader
Project Period 2010-2012

Funding organisation German Research Foundation (DFG)
Project title MyoGrad - International Research Training Group GRK 1631
Project 6: Dysferlinopathy – Sarcolemmal morphology and consequences of gene repair
Speaker University FU and HU Berlin
Function Speaker Berlin and leader of P6
Project Period 2010-2014

Funding organisation German Research Foundation (DFG)
Project title Analysis of nutrient and endocrine signals modifying homeostasis and adipogenesis, P4 (with Prof. Joachim Spranger)
Speaker University Charité
Function Project leader
Project Period 2010-2014


Ten selected Publications

Schoenbeck S; Hammen MJ; Kagnoff MF. (1989) Vicia Villosa adherence separates freshly isolated T helper cells into interleukin 5 or interleukin 2 producing subsets J. Exp. Med., 169: 1491–1496

Schönbeck S
; Padberg F; Hohlfeld R; Wekerle H. (1992) Transplantation of thymic autoimmune microenvironment to SCID mice: A new model of myasthenia gravis J. Clin. Invest.; 90: 245-250

Spuler S
; Emslie-Smith AM; Engel AG (1998) Amyloid myopathy: An underdiagnosed entity. Ann. Neurol. 43: 719-728

Wenzel K, Zabojszcza J, Carl M, Taubert S, Lass A, Harris CL, Ho M, Schulz H, Hummel O, Hubner N, Osterziel KJ, Spuler S. (2005) Increased susceptibility to complement attack due to downregulation of decay accelerating factor/CD55 in dysferlin-deficient muscular dystrophy. J Immunology. 175: 6219-6225.

Wenzel K, Carl M, Perrot A, Zabojszcza J, Assadi M, Ebeling M, Robinson PN, Kress W, Osterziel KJ, Spuler S. (2006) Novel sequence variants in dysferlin-deficient muscular dystrophy leading to mRNA decay and possible C2-domain misfolding. Human Mutation. 27(6):599-600.

Spuler S, Kalbhenn T, Zabojszcza J, van Landeghem FKH, Ludtke A, Wenzel K, Koehnlein M, Schuelke M, Lüdemann L, Schmidt HH. (2007) Muscle and nerve pathology in Dunnigan familial partial lipodystrophy. Neurology 68(9):677-683.

Spuler S, Carl M, Zabojszcza J, Straub V, Bushby K, Moore SA, Bähring S, Wenzel K, Vinkemeier U, Rocken C. (2008) Dysferlin deficient muscular dystrophy features amyloidosis. Ann Neurol. 63(3):323-328.

Schmidt S, Vieweger A, Obst M, Gross V, Mueller S, Steinbrink J, Gutberlet M, Misselwitz B, Luedemann L, Spuler S. (2009) Gadofluorine M enhanced MR imaging enables differentiation of diseased from non diseased muscle in a model of dysferlin-deficient muscular dystrophy in mice. Radiology. 250(1):87-94.

Knoblauch H, Geier C, Adams S, Budde B, Rudolph A, Schulz-Menger J, Spuler A, Ben Yaou R, Nürnberg, P, Voit T, Bonne G, Spuler S. (2010) Contractures and hypertrophic cardiomyopathy in a novel FHL1 mutation. Ann Neurol, 67: 136-140

Knoblauch H*, Schöwel V*, Kress W, Kassner U, Spuler S. (2010) Another side to statin related side effects. Ann Int Med, 152: 478-479 (*contributed equally)