Projects KFO 192

The German Research Foundation (DFG) established our clinical research group (KFO 192) entitled, "Regulation and dysregulation of skeletal muscle growth", in Berlin in 2007. At that time, our group was the only coordinated DFG program in skeletal muscle disease research in Germany. The initiative focused on the interplay between muscular structural changes and their metabolic consequences. We initiated research projects engaged in the role of various muscle proteins such as titin (P1) or dysferlin (P6). We are interested in specific structures of skeletal muscle like caveolae (P7, P9). The pathophysiology behind acquired disorders, such as critical illness myopathy (P3), and muscle loss accompanying weight reduction (P12) is being investigated. We also try to understand why so many patients cannot tolerate statins. The proteasome of skeletal muscle and muscle hormones like myostatin regulate muscle mass and are studied in projects P12 and P6. In P11 we explore mechanisms of embryonic muscle development and regeneration. KFO192 brought together an interdisciplinary team of clinicians, geneticists, cell and molecular biologists, endocrinologists, anesthesiologists, pediatricians, neurologists, and bioinformatics specialists.