Publications Clinical Research Group 192

2007- 2014

Only peer-reviewed paper published or accepted for publication are listed here.

Tobias Timmel, Markus Schuelke, and Simone Spuler: Identifying Dynamic Membrane Structures with Atomic-Force Microscopy and Confocal Imaging. Microscopy and Microanalysis. Published online first: 13 February 2014.

Koch S, Wollersheim T, Bierbrauer J, Haas K, Mörgeli R, Deja M, Spies CD, Spuler S, Krebs M, Weber-Carstens S. Long term Recovery in Critical Illness Myopathy is complete contrary to Polyneuropathy. Muscle Nerve. 2014 Jan 10.

Pakula A, Schneider J, Janke J, Zacharias U, Schulz H, Hübner N, Mähler A, Spuler A, Spuler S, Carlier P, Boschmann M. Altered expression of cyclin A 1 in muscle of patients with facioscapulohumeral muscle dystrophy (FSHD-1). PLoS One. 2013 Sep 3;8(9):e73573.

Raith M, Valencia RG, Fischer I, Orthofer M, Penninger JM, Spuler S, Rezniczek GA, Wiche G. Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by estabilizing microtubule networks in mdx myofibers. Skelet Muscle. 2013 Jun 12;3(1):14.

Weber-Carstens S, Schneider J, Wollersheim T, Assmann A, Bierbrauer J, Marg A, Al Hasani H, Chadt A, Wenzel K, Koch S, Fielitz J, Kleber C, Faust K, Mai K, Spies CD, Luft FC, Boschmann M, Spranger J, Spuler S. Critical illness myopathy and GLUT4 – significance of insulin and muscle contraction. Am J Resp Crit Care Med. 2013 Feb 15;187(4):387-96

Schoewel V, Marg A, Kunz S, Overkamp T, Siegert Carrazedo R, Zacharias U, Daniel PT, Spuler S. Dysferlin-Peptides Reallocate Mutated Dysferlin Thereby Restoring Function. PloS one. 2012;7(11):e49603.

Marg A, Schoewel V, Timmel T, Schulze A, Shah C, Daumke O, Spuler S. Sarcolemmal repair is a slow process and includes EHD2. Traffic. 2012 Sep;13(9):1286-94. doi: 10.1111/j.1600-0854.2012.01386.x. Epub 2012 Jun 29.

Philippi S, Bigot A, Marg A, Mouly V, Spuler S, Zacharias U Dysferlin-deficient immortalized human myoblasts and myotubes as a useful tool to study dysferlinopathy. PLoS Curr. 2012; 4: RRN1298

Zacharias U., Purfürst B., Schöwel V., Morano I., Spuler S., and Haase H.: Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release. J Muscle Res Cell Motil. 2011; 32(4-5): 271-80

Rajab A, Straub V, McCann LJ, Seelow D, Varon R, Barresi R, Schulze A, Lucke B, Lützkendorf S, Karbasiyan M, Bachmann S, Spuler S, Schuelke M. Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. PLoS Genet. 2010 Mar 12;6(3):e1000874.

Knoblauch H*, Schoewel V*, Kress W, Rosada A, Spuler S. Another side to statin-related side effects. Ann Intern Med. 2010 Apr 6;152(7):478-9. Erratum in: Ann Intern Med. 2010 May 18;152(10):688 (*contributed equally)

Boschmann M, Engeli S, Moro C, Luedtke A, Adams F, Gorzelniak K, Rahn G, Mähler A, Dobberstein K, Krüger A, Schmidt S, Spuler S, Luft FC, Smith SR, Schmidt HHJ, Jordan J. LMNA mutations, skeletal muscle lipid metabolism, and insulin resistance. J Clin Endocrin Metab 2010 Feb 3 Epub ahead of print

Knoblauch H, Geier C, Adams S, Budde B, Rudolph A, Zacharias U, Schulz-Menger J, Spuler A, Ben Yaou R, Nürnberg, P, Voit T, Bonne G, Spuler S. Contractures and hypertrophic cardiomyopathy in a novel FHL1 mutation. Ann Neurol, 2010; 67:136–140

Utz W, Schmidt S, Schulz-Menger J, Luft FC, Spuler S. Cardiac involvement in sporadic inclusion body myositis. Circulation, 2010; 121: 706-8

Weber-Carstens S, Koch S, Spuler S, Spies CD, Bubser F, Wernecke KD, Deja M. Nonexcitable muscle membrane predicts intensive care unit-acquired paresis in mechanically ventilated, sedated patients. Crit Care Med, 2009, 37: 2632-2637

Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H, Lüscher TF, Bart B, Banasiak W, Niegowska J, Kirwan BA, Mori C, von Eisenhart Rothe B, Pocock SJ, Poole-Wilson PA, Ponikowski P; FAIR-HF Trial Investigators. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009 Dec 17;361(25):2436-48.

Spuler S, Krug H, Klein C, Chaure-Medialdea I, Jakob W, Ebersbach G, Gruber D, Hoffmann KT, Trottenberg T, Kupsch A. Myopathy causing camptocormia in idiopathic Parkinson's disease: a multidisciplinary approach. Movement Dis, 2009 Epub ahead of print

Ottenheijm CA, Hidalgo C, Rost K, Gotthardt M, Granzier H. Altered contractility of skeletal muscle in mice deficient in titin's M-band region. J Mol Biol. 2009 Oct 16;393(1):10-26.

Szabo T, von Haehling S, Habedank D, Rauchhaus M, Lainscak M, Sandek A, Schefold J, Anker SD, Doehner W. Usefulness of minimal modelling to assess impaired insulin sensitivity in patients with chronic heart failure. Int J Cardiol. 2009 Sep 4. Epub ahead of print

Mai K, Andres J, Biedasek K, Weicht J, Bobbert T, Sabath M, Meinus S, Reinecke F, Möhlig M, Weickert MO, Clemenz M, Pfeiffer AF, Kintscher U, Spuler S, Spranger J. Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21. Diabetes 2009 58:1532-8.

Spuler S, Carl M, Zabojszcza J, Straub V, Bushby K, Moore SA, Bähring S, Wenzel K, Vinkemeier U, Rocken C. Dysferlin deficient muscular dystrophy features amyloidosis. Ann Neurol, 2008, 63: 323-328

Geier C, Gehmlich K, Ehler E, Hassfeld E, Perrot A, Hayess K, Cardim N, Wenzel K, Erdmann B, Krackhardt F, Posch M, Bublak A, Nägele H, Scheffold T, Chien KR, Dietz R, Osterziel KJ, Spuler S, Fuerst DO, Nürnberg P, Özcelik C. Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. Hum Mol Gen. 2008, 17: 2753-2765

Schmidt S, Vieweger A, Obst M, Gross V, Mueller S, Steinbrink J, Gutberlet M, Misselwitz B, Luedemann L, Spuler S. Gadofluorine M enhanced MR imaging enables differentiation of diseased from non diseased muscle in a model of dysferlin-deficient muscular dystrophy in mice. Radiology, 2009, 250: 87-94.

Marg A, Meyer T, Vigneron M, Vinkemeier U. Microinjected antibodies interfere with protein nucleoplasmic shuttling by distinct molecular mechanisms. Cytometry A, 2008, 73A: 1128-1140

Wenzel K, Geier C, Qadri F, Hubner N, Schulz H, Erdmann B, Gross V, Bauer D, Dechend R, Dietz R, Osterziel KJ, Spuler S*, Ozcelik C* (*contributed equally) Dysfunction of dysferlin-deficient hearts. J Mol Med, 2007, 85: 1203-1214